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Tafamidis binding site occupancy and transthyretin stabilization in ATTR-CM

In this learning journey you will:

  • Explore the mechanism of disease of Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
  • Deep dive into the mechanism of action of Tafamidis in ATTR-CM
  • Recognize the importance of the characterization of Tafamidis as a selective stabilizer of TTR
  • Understand the importance and implications of timely treatment for patients with ATTR-CM
  • Review modeling data that supports TTR stabilization as a clinically effective method of treatment for ATTR-CM
Home page journey desciption

Venous thromboembolism is a leading cause of death in patients with cancer.

Khorana AA et al. J Thromb Haemost. 2007;5:632-634

Reference

1. Khorana AA et al. J Thromb Haemost. 2007;5:632-634

2. Agnelli G et al. N Engl J Med. 2020;382:1599-1607.

Ca-VTE Incidence and Risk

Mechanism of Disease ATTR-CM

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Cancer-associated VTE Risk Factors

Tafamidis Mechanism of Action in ATTR-CM

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Pulmonary Embolism

Publication: Binding Site Occupancy in ATTR-CM

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Mechanisms of Thrombosis in Pancreatic or Stomach Cancer

Relationship of Binding Site Occupancy in TTR Stabilization

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CARAVAGGIO Video

Discussion: Receptor Occupancy Modeling Study

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