Limitations1
- Small sample sizes and limited data on women
- The majority of data were derived from case series rather than cohort studies, impeding direct comparison of data between women and men
- Heterogeneity:
- Stage patients were recruited
- Statistical reporting of data (e.g., means vs. medians)
- Time frames and duration of follow-up (i.e., from onset or time of biopsy or pre- and post-liver transplant to variable follow-up visit or death)
- Criteria used to confirm the presence of ATTR-CM (e.g., interventricular septal thickness >12 mm, positive biopsy or scintigraphy) may have biased patient selection and may have been inaccurate for identifying women with ATTR-CM
