Lag Time Between Onset of Symptoms and Diagnosis1-3

Transthyretin Amyloid Cardiomyopathy   >   ATTR-CM   >   Lag Time Between Onset of Symptoms and Diagnosis
Typically, a patient’s condition deteriorates due to unrecognized disease progression, and diagnosis usually follows manifestations of serious cardiac symptoms1,2
 
Manifestation Median Days to Diagnosis
Carpal Tunnel Syndrome 1,617
Erectile Dysfunction* 1,268
Ocular Problems* 1,158
Peripheral Neuropathy* 960
Dyspnea 470
Orthostasis 465
Permanent Pacemaker 453
Bundle Branch / Atrioventricular Block 311
Atrial Fibrillation 275
Chronic Diarrhea / Constipation* 240
Low Voltage on ECG 162
LV Hypertrophy 116
Stroke 78
Diagnosis
 
Carpal Tunnel Syndrome
  • Often the earliest manifestation of ATTR-CM and is the most common non-cardiac manifestation1
  • Found in approximately 50% of individuals with ATTRwt, 5-7 years before diagnosis3

*Specific to ATTRv only