Confirming Suspicion of ATTR-CM: Non-Invasive Imaging Technique
- Nuclear scintigraphy is a non-invasive, diagnostic tool1 [also referred to as "PYP scan" or "bone scintigraphy"]
- 99mTechnetium-pyrophosphate (99mTc-PYP) is a bone imaging radiotracer but not FDA-approved for diagnosis of ATTR-CM. Use of 99mTc-PYP to aid ATTR-CM diagnosis has been increasing in the U.S.*1
- The combined finding of grade 2 or 3 cardiac uptake on radionuclide scintigraphy and the absence of a monoclonal protein by serum and urine immunofixation and by serum free light chain measurement was 100% specific for presence of ATTR-CM (positive predictive value confidence interval, 98.0–100)2
- If clinical suspicion remains high for ATTR-CM in spite of a negative or inconclusive scintigraphy scan biopsy should be considered
*Bone scintigraphy is not FDA approved for the diagnosis of ATTR-CM. Please consult individual labeling for risks
