Confirming Suspicion of ATTR-CM: Tissue Typing After Biopsy1-5
Provide definitive etiologic classification of the amyloidogenic protein1,2 Achieve a definitive classification to help rule out AL amyloidosis1
Immunohistochemistry3
| Technetium pyrophosphate myocardial uptake and peripheral neuropathy in a rare variant of familial TTR amyloidosis (Ser23Asn). |
|
Mass Spectrometry4
Intensity (AU)
80000
60000
40000
20000
0
11322.0m/z (M + 2H)2+
11000
11500
12000
A negative biopsy may not rule out cardiac amyloidosis5
Sensitivity of the biopsy depends on tissue location, pathologist tissue sample technique, tissue staining technique, and the varied distribution of amyloid deposits in the organ biopsied
Sensitivity of the biopsy depends on tissue location, pathologist tissue sample technique, tissue staining technique, and the varied distribution of amyloid deposits in the organ biopsied
