Association between ATTRwt Deposits and Orthopedic Conditions1-7
CARPAL TUNNEL
SYNDROME
In 2 studies among patients with wild type transthyretin amyloid cardiomyopathy (ATTRwt-CM), 46%–49% had carpal tunnel syndrome2,3
LUMBAR SPINAL
STENOSIS
ATTRwt deposits have been identified in 44% of resected tissues in patients undergoing lumbar spinal stenosis surgery4
OTHER ORTHOPEDIC
MANIFESTATIONS
- 33% of patients with ATTRwt-CM reported spontaneous rupture of the distal biceps tendon5
- 24% of tissue samples removed during surgery for rotator cuff repair were found to have ATTRwt deposits6
- Total knee and hip arthroplasty was 3 to 5 times more common among patients with ATTR-CM amyloidosis than age- and sex-matched controls7
