Pfizer - Estimated Prevalence in HFpEF or Aortic Stenosis

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Estimated Prevalence of Amyloid Deposits: Patients with HFpEF or Aortic Stenosis^1-5

Transthyretin Amyloid Cardiomyopathy > ATTR-CM > Prevalence > Estimated Prevalence in HFpEF or Aortic Stenosis

HFpEF

17% incidence of ATTRwt myocardial deposits found during autopsies of older patients with HFpEF (40% in those ≥80 years at diagnosis)¹
13% of hospitalized older patients with HFpEF with LV wall thickness ≥12 mm were found to have ATTR-CM²
10% of HFpEF clinic referrals (Johns Hopkins) had biopsy-proven ATTR-CM³

AORTIC STENOSIS

6% of patients with severe aortic stenosis undergoing surgical valve replacement had ATTR-CM⁴
In patients aged >65 years referred for TAVR, 16% overall and 22% of men had ATTR-CM⁵