ATTR-CM in Women1

Transthyretin Amyloid Cardiomyopathy   >   Additional Information   >   Gender Differences   >   ATTR-CM in Women: Introduction

Introduction
  • The frequency of ATTR-CM, particularly wild-type, is reportedly lower in women than men, and the female sex has been proposed as a protective factor
  • Some studies with higher proportions (>50%) of women with wild-type ATTR suggest that ATTR-CM may be further underdiagnosed and/or misdiagnosed in women because of sex-related differences in clinical presentation or disease characteristics
  • Presumption of male predominance of wild-type and hereditary ATTR-CM may lower clinical suspicion of the disease when “red flags” are observed in women