Echocardiogram (ECHO)1-3

Transthyretin Amyloid Cardiomyopathy   >   Raising Suspicion of ATTR-CM   >   Cardiac Assessments
  • Increased LV wall thickness
  • Thickening of the atrioventricular valves and interatrial septum
  • Speckled, granular appearance of the myocardium (not always present)
  • Normal or near-normal LV ejection fraction (often present)
  • Abnormal function
  • Diastolic dysfunction with impaired relaxation
  • Pericardial effusion

Longitudinal strain in apical 4-, 2-, and 3-chamber views showing severely reduced global longitudinal strain of −12.5% with an apical to basal strain ratio of 2.7. Strain imaging in CA typically results in a “bull’s-eye” deformation pattern (bottom right, or “H”).