Pfizer - Patient Genotypes

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Always Use Immunofixation to Rule Out Light Chain Amyloidosis^1-3

Heightened
suspicion of Cardiac
Amyloidosis

Serum Free Light
Chains Assay

Serum
Electrophoresis

Urine
Electrophoresis

Immunofixation

Increased Sensitivity For Light Chain Amyloidosis

98%¹

Ensure that the laboratory is consulted and understands why immunofixation
should always be applied to rule out Light Chain Amyloidosis

	n	All the 5 tests	Serum PEL and IFE; urine IFE	Serum PEL, IFE, and FLC	Serum PEL and FLC	Serum IFE	Serum PEL	Serum FLC

Diagnosis, n
All	1877	1851	1821	1828	1770	1632	1482	1395
MM	467	467	461	467	467	441	409	452
Macroglobulinemia	26	26	26	26	26	26	26	19
SMM	191	191	191	191	190	188	180	155
MGUS	524	524	524	509	465	468	429	222
Plasmacytoma	29	26	26	26	25	21	21	16
POEMS	31	30	30	30	23	30	23	3
Extramedullary plasmacytoma	10	2	2	1	1	1	1	1
Primary AL	581	570	547	564	559	429	382	513
LCDD	18	15	14	14	14	10	10	14
Diagnosis, %
All		98.6	97.0	97.4	94.3	87.0	79.0	74.3
MM		100.0	98.7	100.0	100.0	94.4	87.6	96.8
Macroglobulinemia		100.0	100.0	100.0	100.0	100.0	100.0	73.1
SMM		100.0	100.0	100.0	99.5	98.4	94.2	81.2
MGUS		100.0	100.0	97.1	88.7	92.8	81.9	42.2
Plasmacytoma		89.7	89.7	89.7	88.2	72.4	72.4	55.2
POEMS		96.8	96.8	96.8	74.2	96.8	74.2	9.7
Extramedullary plasmacytoma		70.0	20.0	10.0	10.0	10.0	10.0	10.0
Primary AL		98.1	94.2	97.1	96.2	73.8	65.9	88.3
LCDD		83.3	77.8	77.8	77.8	55.6	55.6	77.8