Discussion1
Clinical Presentation and Disease Characteristics

Transthyretin Amyloid Cardiomyopathy   >   Additional Information   >   Gender Differences   >   ATTR-CM in Women: Discussion

Trends Suggestive of Sex-based Differences

  • Lower interventricular, septal and posterior wall thickness and higher LV ejection fractions were reported in women compared with men

Disparity Between Sexes in
ATTR-CM Frequency

  • Cardioprotective effects of estrogen
  • Smaller heart structures in women that do not meet diagnostic thresholds for ATTR-CM
  • Lack of awareness of red flags for ATTR-CM in women compared with men
  • Women with ATTR-CM could be at risk of potential underdiagnosis because they are less likely to meet the diagnostic wall thickness threshold
  • Further research is needed to determine if lower cut off values for cardiac dimensions in women will affect rates of suspicion and diagnosis