ATTR-CM Subtypes: Wild-Type and Hereditary*1-3
Transthyretin Amyloidosis†
WILD-TYPE
ATTR cardiomyopathy1,4,5
HEREDITARY‡
ATTR cardiomyopathy3,5
e.g., V122I, T60A
e.g., V122I, T60A
Mixed ATTR cardiomyopathy/
polyneuropathy3
e.g., V30M (late onset)
polyneuropathy3
e.g., V30M (late onset)
ATTR polyneuropathy3,5
e.g., V30M (early onset)
e.g., V30M (early onset)
*Caused by inherited mutations in the transthyretin gene TTR (ATTRm, ATTRv) or deposition of genetically normal, wild-type transthyretin protein (ATTRwt).
The mutations shown above are representative of the phenotype but are not an exhaustive list.
†The clinical presentation in ATTR differs according to the underlying mutation.
‡The mutations shown above are the most common mutations in ATTR.6
