ATTR-CM: A Type of Cardiomyopathy Arising from Destabilization of the TTR Tetramer1-10

ATTR-CM is a fatal, underrecognized, underdiagnosed type of cardiomyopathy caused by aggregated misfolded proteins, called amyloid fibrils, that accumulate in the myocardium1-7

Amyloidogenic TTR Cascade8,9
Liver
Transthyretin (TTR)
Dissociation
Misfolding
Amyloid fibrils
accumulate in different
parts of the body, such
as the heart
Rate-determining
step in amyloidosis10