Main Types of Cardiac Amyloidosis1-4

Transthyretin Amyloid Cardiomyopathy   >   Cardiac Amyloidosis Overview
  • Amyloidosis is a group of systemic diseases characterized by organ deposition of misfolded protein fragments1
  • Characterized by extracellular deposition of misfolded protein, which forms amyloid fibrils that deposit in the heart3-4
CARDIAC AMYLOIDOSIS1-4
Immunoglobulin
(or amyloid)
light-chain (AL)
amyloidosis1-4*		 Transthyretin
amyloid
cardiomyopathy
(ATTR-CM)1-3
Account for more than
95% of all cardiac amyloidosis diagnoses2
Others including2,3
  • Serum amyloid A
  • Apolipoprotein A1
  • Immunoglobulin heavy chain
  • Fibrinogen alpha chain
  • Gelsolin

*It is important to clinically differentiate between ATTR and AL, as they have different clinical courses, and AL requires immediate treatment.2