Amyloidosis: A Systemic, Multi-organ Disease1-6

Transthyretin Amyloid Cardiomyopathy   >   Cardiac Amyloidosis Overview
  • Cardiac Amyloidosis – only one aspect of a systemic disease with multi-organ involvement1
  • Almost any tissue can be affected by deposition of amyloid fibrils2
  • This contributes to the high rate of misdiagnosis
  • Patients with Cardiac Amyloidosis may seek medical attention for neurological, renal or ophthalmological issues rather than cardiac complaints3
Soft Tissue Infiltrations1,6
  • Macroglossia
  • Rash
  • Bilateral carpal tunnel syndrome
  • Muscle pseudohypertrophy
  • Amyloid lymphadenopathy
  • Arthropathy
Liver and Spleen1,5,6
  • Hepatomegaly without scan defects
  • Elevated alkaline phosphatase,
    gamma glutamyl transpeptidase
  • Splenomegaly
Gastrointestinal Tract1,6
  • Diarrhea and/or constipation
  • Early satiety, weight loss
  • Bleeding
Ophthalmological4
  • Glaucoma
  • Intravitreal deposition
  • Scalloped pupils
Pulmonary1,6
  • Diffuse alveolar infiltrates
  • Nodules
    and tracheobronchial involvement
  • Pleural effusions
  • Breathlessness, cough
Nervous System1,2,5,6
  • Peripheral neuropathy;
    sensorimotor polyneuropathy and
    neuropathic pain
  • Autonomic dysfunction:
    Orthostatic hypotension,
    gastroparesis, erectile dysfunction