Findings That Raise Suspicion of ATTR-CM1
Reduction in longitudinal strain with
apical sparing
apical sparing
Marked ECV expansion, abnormal nulling
time for the myocardium, or diffuse late
gadolinium enhancement on CMR
time for the myocardium, or diffuse late
gadolinium enhancement on CMR
Discrepancy between left ventricular
thickness and QRS voltage*
thickness and QRS voltage*
Mild increase in troponin levels on
repeated occasions
repeated occasions
Atrioventricular block, in the presence of
increased left ventricular wall thickness
increased left ventricular wall thickness
Symptoms of polyneuropathy
and/or dysautonomia
and/or dysautonomia
Echocardiographic hypertrophic phenotype with
associated infiltrative features†
associated infiltrative features†
History of bilateral carpal
tunnel syndrome
tunnel syndrome
