Mayo Model (ATTRwt):
Risk Stratification Using Troponin T and NT-proBNP1

Transthyretin Amyloid Cardiomyopathy   >   Additional Information   >   Biomarkers and Prognostic Staging   >   Risk Stratification
ATTRwt: Mortality-Troponin T
+
Death, %
100
75
50
25
0
P<0.001
Years
0
2
4
6
>0.05 ng/mL     ≤0.05 ng/mL
 
≤0.05 103 59 21 9
>0.05 51 19 5 2
Stage Median Survival
(months)		 Hazard Ratio† For
Death (95% CI)
1 66 Reference
2 40 1.4 (0.8-2.6)
3 20 3.6 (2.0-6.4)
ATTRwt: Mortality-NT-BNP
+
Death, %
100
75
50
25
0
P<0.001
Years
0
2
4
6
≤3000 pg/mL     ≤3000 pg/mL
 
≤3,000 80 44 15 8
>3,000 74 34 11 3
†Numbers in the boxes above represent number of subjects at risk at each time point
ATTRwt: Staging System
+
Death, %
100
75
50
25
0
P<0.001
Expected
Stage I
Stage II
Stage III
Years
0
2
4
6
Two Above   One Above      Neither   Expected
Neither 68 38 13 7
One Above 47 27 10 3
Two Above 39 13 3 1